Oxycodone to Oxymorphone Metabolism - Practical Pain …
Oxycodone is metabolized in part by cytochrome P450 2D6 to oxymorphone, which represents less than 15% of the total administered dose.⁶ However, oxymorphone has a significantly longer half life (7-9 hours)⁷ than does oxycodone, whose mean elimination half-life following a single, oral dose is 3.51 ± 1.43 hours.⁸ It is therefore plausible ...
Đọc thêm